Nucleus Biologics Launches New Device to Make Cell Food Supply Chain Faster and Cheaper

The San Diego based company Nucleus Biologics solved its own problem by launching an eco-friendly device that can cut R&D costs and work smart.

Nucleus Biologics introduced the Krakatoa K500 device last week at the Advanced Therapies Conference in San Diego. David Sheehan, founder and CEO of Nucleus Biologics refers to it as a "cellular Nespresso.” Up to 500 liters of the sterile solution can be prepared for the lab or clinic in three hours by adding it in a pod with the specific powder.

Scientists use temperature-controlled trucks to transport vats of liquid that are used for cell growth throughout the country. Because it's so important to keep the substances under control clean, these vats are heavy and require a lot of maintenance and Sheehan considers this as a logistical nightmare and incredibly expensive.

Sheehan explained that it was not uncommon that the cost of the shipping was sometimes more than the cost of the media. So he solved his own problem, inventing a machine that dispenses cell food on the spot. Adding to this, Parinitha Sharma, commercial operations manager at Nucleus Biologics said that normal process and timeline for creating 500 liters is probably close to at least an eight-hour shift with three technicians, but with the Krakatoa K500 device it can be reduced to 3 hours.

Sharma demonstrated the production of this cell nourishment by taking a tour of the 7,000-square-foot facility owned by Nucleus Biologics. Powders are measured out in two dry rooms, mixing vats are kept in four liquid cleanrooms, and cell food is packed and stored in a clean area at a different manufacturing facility before being transported to labs and clinics around the nation, frequently in a temperature-controlled truck.

Cell feeding alone can account for up to 50% of R&D costs, causing a significant barrier to accessing new cell and gene therapies. Nucleus Biologics plans to replace some of its manufacturing equipment with the Krakatoa K500 device. The device was called after Krakatoa's volcanic explosion in 1883, which was recognized as the loudest sound ever recorded. "We felt like this product was that disruptive," Sheehan stated. The technology could cut greenhouse gas emissions by 65%. Furthermore, the machine costs $400,000, and the company has sold two to date.